Chen, M. et al. Micropollutants but high risks: human multiple stressors increase risks of freshwater ecosystems at the megacity-scale. J. Hazard. Mater. 460, 132497. https://doi.org/10.1016/j.jhazmat.2023.132497 (2023).
Ren, H., Troger, R., Ahrens, L., Wiberg, K. & Yin, D. Screening of organic micropollutants in Raw and drinking water in the Yaggtze river delta, China. Environ. Sci. Europe. 32, 67. https://doi.org/10.1186/s12302-020-00342-5 (2020).
Kumar, V. et al. Global evaluation of heavy metal content in surface water bodies: A meta-analysis using heavy metal pollution indices and multivariate statistical analyses. Chemosphere 236, 124364. https://doi.org/10.1016/j.chemosphere.2019.124364 (2019).
Dragon, K., Drożdżyński, D., Górski, J. & Kruć, R. The migration of pesticide residues in groundwater at a bank filtration site (Krajkowo well field, Poland). Environ. Earth Sci. 78, 593. https://doi.org/10.1007/s12665-019-8598-0 (2019).
Elfikrie, N., Ho, Y. B., Zaidon, S. Z., Juahir, H. & Tan, E. S. S. Occurrence of pesticides in surface water, pesticides removal efficiency in drinking water treatment plant and potential health risk to consumers in Tengi river basin, Malaysia. Sci. Total Environ. 712, 136540. https://doi.org/10.1016/j.scitotenv.2020.136540 (2020).
Kruć-Fijałkowska, R., Dragon, K., Drożdżyński, D. & Górski, J. Seasonal variation of pesticides in surface water and drinking water wells in the annual cycle in Western poland, and potential health risk assessment. Sci. Rep. 12, 1. https://doi.org/10.1038/s41598-022-07385-z (2022).
Dragon, K., Górski, J., Kruć, R., Drożdżyński, D. & Grischek, T. Removal of natural organic matter and organic micropollutants during riverbank filtration in krajkowo, Poland. Water 10, 1457. https://doi.org/10.3390/w10101457 (2018).
Kruć-Fijałkowska, R., Dragon, K. & Drożdżyński, D. Factors affecting the concentrations of pharmaceutical compounds in river and groundwaters: efficiency of river bank filtration (Mosina-Krajkowo well field, Poland). Geol. Q. 66, 3. https://doi.org/10.7306/gq.1635 (2022).
Li, W. C. Occurrence, sources, and fate of pharmaceuticals in aquatic environment and soil. Environ. Pollut. 187, 193–201. https://doi.org/10.1016/j.envpol.2014.01.015 (2014).
Huang, Q., Liu, M., Cao, X. & Liu, Z. Occurrence of microplastics pollution in the Yangtze river: distinct characteristics of Spatial distribution and basin-wide ecological risk assessment. Water Res. 229, 119431. https://doi.org/10.1016/j.watres.2022.119431 (2023).
Nikolaou, A. D., Sureyya, M. & Fatta, D. Occurrence patterns of pharmaceuticals in water and wastewater environments. Anal. Bioanal Chem. 387, 1225–1234. https://doi.org/10.1007/s00216-006-1035-8 (2007).
Alder, A. C., Schaffner, C., Majewsky, M., Klasmeier, L. & Fenner, K. Fate of β-blocker human pharmaceuticals in surface water: comparison of measured and simulated concentrations in the Glatt Valley watershed, Switzerland. Water Res. 44, 3, 936–948. https://doi.org/10.1016/j.watres.2009.10.002 (2010).
Bandala, E. R. et al. Impacts of COVID-19 pandemic on the wastewater pathway into surface water: a review. Sci. Total Environ. 774, 145586. https://doi.org/10.1016/j.scitotenv.2021.145586 (2021).
Macedo, H. E. et al. Distribution and characteristics of wastewater treatment plants within the global river network. Earth Syst. Sci. Data. 14, 559–577. https://doi.org/10.5194/essd-14-559-2022 (2022).
Matesun, J., Petrik, L., Musvoto, E., Ayinde, W. & Ikumi, D. Limitations of wastewater treatment plants in removing trace antropogenic biomarkers and future directions: A review. Ecotoxicol. Environ. Saf. 281, 116610. https://doi.org/10.1016/j.ecoenv.2024.116610 (2024).
Dai, H., Wang, C., Yu, W. & Han, J. Tracing COVID-19 drugs in the environment: are we focusing on the right environmental compartment? Environ. Pollut. 339, 122732. https://doi.org/10.1016/j.envpol.2023.122732 (2023).
Sui, Q. et al. Occurrence, sources and fate of pharmaceuticals and personal care products in the ground water: a review. Emerg. Contaminants. 1, 14–24. https://doi.org/10.1016/j.emcon.2015.07.001 (2015).
Ślósarczyk, K., Jakóbczyk-Karpierz, S., Różkowski, J. & Witkowski, A. J. Occurrence of pharmaceuticals and personal care products in the water environment of poland: a review. Water 13, 2283. https://doi.org/10.3390/w13162283 (2021).
Kasprzyk-Hordern, B., Dinsdale, R. M. & Guwy, A. J. The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters. Water Res. 43, 2, 363–380. https://doi.org/10.1016/j.watres.2008.10.047 (2009).
Styszko, K., Proctor, K., Castrignano, E. & Kasprzyk-Hordern, B. Occurrence of pharmaceutical residues, personal care products, lifestyle chemicals, illicit drugs and metabolites in wastewater and receiving surface waters of Krakow agglomeration in South Poland. Sci. Total Environ. 768, 144360. https://doi.org/10.1016/j.scitotenv.2020.144360 (2021).
Chaturvedi, K., Vishwakarma, D. K. & Singh, N. COVID-19 and its impact on education, social life and mental health of students: A survey. Child. Youth Serv. Rev. 25, 121, 105866. https://doi.org/10.1016/j.childyouth.2020.105866 (2021).
Hosseinzadeh, P., Zareipour, M., Baljani, E. & Moradali, M. R. Social consequences of the COVID-19 pandemic. A systematic review. Invest. Educ. Enferm. 30, 40, (1), e10. https://doi.org/10.17533/udea.iee.v40n1e10 (2022).
Ventriglio, A., Castaldelli-Maia, J. M., Torales, J., Chumakov, E. M. & Bhugra, D. Personal and social changes in the time of COVID-19. Ir. J. Psychol. Med. 9, 1–3. https://doi.org/10.1017/ipm.2021.23 (2021).
Ilnicka, E., Kasprzyk, D., Ogórek, A., Sternak, A. & Cierpka, A. The COVID-19 pandemic in the experience of people in late adulthood. Psychologia Rozwojowa (in polish). 26, 2, 59–77. https://doi.org/10.4467/20843879PR.21.012.15135 (2021).
Roy, A., Deb, S. & Chakarwarti, D. Impact of COVID-19 on public social life and mental health: a statistical study of Google trends data from the USA. J. Appl. Stat. 51 (3), 581–605. https://doi.org/10.1080/02664763.2022.2164562 (2023).
Zhang, J. et al. The differential psychological distress of populations affected by the COVID-19 pandemic. Brain Behav. Immun. 87, 49–50. https://doi.org/10.1016/j.bbi.2020.04.031 (2020). (2020).
Moccia, L. et al. Affective temperament, attachment style, and the psychological impact of the COVID-19 outbreak: an early report on the Italian general population. Brain Behav. Immun. 87, 75–79. https://doi.org/10.1016/j.bbi.2020.04.048 (2020).
Probst, T., Stippl, P. & Pieh, C. Changes in provision of psychotherapy in the early weeks of the COVID-19 lockdown in Austria. Int. J. Environ. Res. Public. Health. 17, 11, 3815. https://doi.org/10.3390/ijerph17113815 (2020).
Ang, L., Hernandez-Rodriguez, E., Cyriaque, V. & Yin, X. COVID-19’s environmental impacts: challenges and implications for the future. Sci. Total Environ. 899, 165581. https://doi.org/10.1016/j.scitotenv.2023.165581 (2023).
Diffenbaugh, N. S. COVID-19 and the environment: Short-run and potential long-run impacts. Annu. Rev. Environ. Resour. 47, 65–90. https://doi.org/10.1146/annurev-environ-120920-125207 (2022).
Bhat, S. A. et al. Impact of COVID-related lockdowns on environmental and climate change scenarios. Environ. Res. 195, 110839. https://doi.org/10.1016/j.envres.2021.110839 (2021).
Raza, T. et al. Impact assessment of COVID-19 global pandemic on water, environment, and humans. Environ. Adv. 11, 100328. https://doi.org/10.1016/j.envadv.2022.100328 (2023).
Uddin, M. G. et al. Assessing the impact of COVID-19 lockdown on surface water quality in Ireland using advanced Irish water quality index (IEWQI) model. Environ. Pollut. 336, 122456. https://doi.org/10.1016/j.envpol.2023.122456 (2023).
Cipriani-Avila et al. Occurrence of emerging contaminants in surface water bodies of a coastal Province in Ecuador and possible influence of tourism decline caused by COVID-19 lockdown. Sci. Total Environ. 866, 161340. https://doi.org/10.1016/j.scitotenv.2022.161340 (2023).
Ormaza-González, F., Castro-Rodas, D. & Statham, P. COVID-19 impacts on beaches and coastal water pollution at selected sites in ecuador, and management proposals post-pandemic. Front. Mar. Sci. 8, 669374. https://doi.org/10.3389/fmars.2021.669374 (2021).
Zambrano-Monserrate, M. A., Ruano, M. & Sanchez-Alcalde, L. Indirect effects of COVID-19 on the environment. Sci. Total Environ. 728, 138813. https://doi.org/10.1016/j.scitotenv.2020.138813 (2020).
Luczkiewicz, A. et al. Wastewater quality during the COVID-19 pandemic: a retrospective analysis of Polish case study. Int. J. Environemntal Sci. Technol. 22, 4125–4142. https://doi.org/10.1007/s13762-024-05934-9 (2025).
Tokatli, C. & Varol, M. Impact of the COVID-19 lockdown period on surface water quality in the Meriç-Ergene river basin, Northwest Turkey. Environ. Res. 111051 https://doi.org/10.1016/j.envres.2021.111051 (2021).
Chakraborty, B. et al. Positive effects of COVID-19 lockdown on river water quality: evidence from river damodar, India. Sci. Rep. 11, 20140. https://doi.org/10.1038/s41598-021-99689-9 (2021).
Qiao, X. et al. Surface water quality in the upstream-most megacity of the Yangtze river basin (Chengdu): 2000–2019 trends, the COVID-19 lockdown effects, and water governance implications. Environ. Sustain. Indic. 10, 100118. https://doi.org/10.1016/j.indic.2021.100118 (2021).
Singh, M., Pandey, U. & Pandey, J. Effects of COVID-19 lockdown on water quality, microbial extracellular enzyme activity, and sediment-P release in the Ganga river, India. Environ. Sci. Pollut Control Ser. 29, 60968–60986. https://doi.org/10.1007/s11356-022-20243-9 (2022).
Yunus, A. P., Masago, Y. & Hijioka, Y. COVID-19 and surface water quality: improved lake water quality during the lockdown. Sci. Total Environ. 731, 139012. https://doi.org/10.1016/j.scitotenv.2020.139012 (2020).
Gwenzi, W. et al. COVID-19 drugs in aquatic systems: a review. Environ. Chem. Lett. 20, 1275–1294. https://doi.org/10.1007/s10311-021-01356-y (2022).
Love, J. S., Blumenberg, A. & Horowitz, Z. The parallel pandemic: medical misinformation and COVID-19: Primum Non nocere. J. Gen. Intern. Med. 35, 2435–2436. https://doi.org/10.1007/s11606-020-05897-w (2020).
Olesch, A. et al. Pol. Health J. (2022). https://issuu.com/polishhealthcarejournal/docs/01_2022_osoz?utm_medium=referral&utm_source=blog.osoz.pl
Diaz-Calam, N. et al. Consumption and occurrence of antidepressants (SSRIs) in pre- and post-COVID-19 pandemic, their environmental impact and innovative removal methods: A review. Sci. Total Environ. 829, 154656. https://doi.org/10.1016/j.scitotenv.2022.154656 (2022).
Pashaei, R. et al. Pharmaceutical and microplastic pollution before and during the COVID-19 pandemic in surface water, wastewater, and groundwater. Water 14, 3082. https://doi.org/10.3390/w14193082 (2022).
Wojcieszyńska, D., Guzik, H. & Guzik, U. Non-steroidal anti-inflammatory drugs in the era of the COVID-19 pandemic in the context of the human and the environment. Sci. Total Environ. 834, 155317. https://doi.org/10.1016/j.scitotenv.2022.155317 (2022).
Antos, J. et al. Monitoring of contamination of the warta river in Poznan by non-steroidal anti-inflammatory drugs and antibiotics. Water 15, 2716. https://doi.org/10.3390/w15152716 (2023).
Azanu, D., Adu-Poku, D., Saah, S. A. & Appaw, W. O. Prevalence of pharmaceuticals in surface water samples in Ghana. J. Chem. 477 https://doi.org/10.1155/2021/7829477 (2021).
Ma, N. et al. Distribution of antibiotics in lake water-groundwater-sediment system in Chenhu lake area. Environ. Res. 204, 112343. https://doi.org/10.1016/j.envres.2021.112343 (2022).
Nason, S. L. et al. Changes in sewage sludge chemical signatures during a COVID-19 community lockdown, part 1: traffic, drugs, mental health, and disinfectants. Environ. Toxicol. Chem. 41, 1179–1192. https://doi.org/10.1002/etc.5217 (2022).
Stipanicev, D. et al. COVID-19 lockdowns—Effect on concentration of pharmaceuticals and illicit drugs in two major Croatian rivers. Toxics 10, 241. https://doi.org/10.3390/toxics10050241 (2022).
Petromelidou, S. et al. Exploring patterns of antibiotics during and after COVID-19 pandemic in wastewaters of Northern greece: potential adverse effects on aquatic environment. Sci. Total Environ. 914, 169832. https://doi.org/10.1016/j.scitotenv.2023.169832 (2024).
Pielach, M. & Mizerna-Nowotna, P. Lewobrzeżna Oczyszczalnia Ścieków Dla Miasta Poznania – testy Redukcji Siarkowodoru Przy Użyciu chemii – etap II. Forum Eksploatatora. 1, 94, 32–34 (2018). (in Polish).
Ilnicki, P., Farat, R., Górecki, K. & Lewandowski, P. Impact of Climatic change on river discharge in the driest region of Poland. Hydrol. Sci. J. 59 (6). https://doi.org/10.1080/02626667.2013.831979 (2014).
Marsz, A. A., Sobkowiak, L., Styszyńska, A., Wrzesiński, D. & Perz, A. The thermal state of the North Atlantic ocean andhydrological droughts in the warta river catchment in Poland during 1951–2020. Water 15, 2547. https://doi.org/10.3390/w15142547 (2023).
R Core Team. R: A Language and Environment for Statistical Computing: The R Project for Statistical Computing. R version 4.4.3. (2025).
Cucinotta, D. & Vanelli, M. WHO declares COVID-19 a pandemic. Acta Biomed. 91, 1, 157–160. https://doi.org/10.23750/abm.v91i1.9397 (2020).
Ministry of Health. Report of coronavirus (SARS-CoV-2) infections (2021). https://www.gov.pl/web/koronawirus/wykaz-zarazen-koronawirusem-sars-cov-2
Journal of Laws. Item 491 as amended. Regulation of the minister of health of 20 March 2020 regarding the announcement of the state of epidemic in the territory of the Republic of Poland.https://isap.sejm.gov.pl/isap.nsf/DocDetails.xsp?id=WDU20200000491 (2020).
Journal of Laws. Item 1356 as amended. Regulation of the Council of ministers of 7 August 2020 on the introduction of certain restrictions, orders and prohibitions in connection with the occurrence of an epidemic state https://isap.sejm.gov.pl/isap.nsf/DocDetails.xsp?id=WDU20200001356(2020).
Government Security Centre. New rules for covering the nose and mounth, open cinemas and gyms – we are entering the next stage of unfreezing (2021). https://www.gov.pl/web/koronawirus/4-etap-odmrazania
Rzymski, P., Poniedziałek, B. & Fal, A. Willingness to receive the booster COVID-19 vaccine dose in Poland. Vaccines (Basel). 9 (11). https://doi.org/10.3390/vaccines9111286 (2021).
Koronawiruswpolsce.pl Statistics and data on COVID-19. in Poland. https://koronawiruswpolsce.pl. Accessed 29 April 2025.
Institute of Meteorology and Water Management. – National Research Institute. https://www.danepubliczne.imgw.pl. Accessed 15 April 2025.
Zhou, H. et al. Occurrence of selected pharmaceuticals and caffeine in sewage treatment plants and receiving rivers in beijing, China. Water Environ. Res. 82, 11, 2239–2248. https://doi.org/10.2175/106143010X12681059116653 (2010).
Dragon, K. et al. The impact of treated wastewater effluent on contamination of a water supply aquifer during one decade of water exploitation (Tursko well field, Poland). Geol. Q. 66, 14. https://doi.org/10.7306/gq.1646 (2022).
Liu, H-Q. et al. Spatial distribution and removal performance of pharmaceuticals in municipal wastewater treatment plants in China. Sci. Total Environ. 586, 1162–1169. https://doi.org/10.1016/j.scitotenv.2017.02.107 (2017).
Manoiu, V-M., Kubiak-Wójcicka, K., Craciun, A-I., Akman, C. & Akman, E. Water quality and water pollution in time of COVID-19: positive and negative repercussions. Water 14, 1124. https://doi.org/10.3390/w14071124 (2022).
Sadio, A. J. et al. Assessment of self-medication practices in the context of the COVID-19 outbreak in Togo. BMC Public. Health. 21, 58. https://doi.org/10.1186/s12889-020-10145-1 (2021).
Niemi, L. et al. Spatiotemporal trends and annual fluxes of pharmaceutical in a Scottish priority catchment. Environ. Pollut. 292 (A), 118295. https://doi.org/10.1016/j.envpol.2021.118295 (2022).
Chen, X. et al. Occurrence and risk assessment of pharmaceuticals and personal care products (PPCPs) against COVID-19 in lakes and WWTP-river-estuary system in wuhan, China. Sci. Total Environ. 792, 148352. https://doi.org/10.1016/j.scitotenv.2021.148352 (2021).
Usman, M., Farooq, M. & Hanna, K. Environmental side effects of the injudicious use of antimicrobials in the era of COVID-19. Sci. Total Environ. 747, 141053. https://doi.org/10.1016/j.scitotenv.2020.141053 (2020).
Daoud, A. & Ronen, O. Decline in emergency department visits during the COVID-19 quarantine. Am. J. Emerg. Med. 71, 74–90. https://doi.org/10.1016/j.ajem.2023.06.002 (2023).
Mularczyk-Tomaczewska, P. et al. Barriers to accessing health services during the COVID-19 pandemic in poland: A nationwide cross-sectional survey among 109,928 adults in Poland. Front. Public. Health. 8, 10986996. https://doi.org/10.3389/fpubh.2022.986996 (2022).
NIZP-PIB. Adverse post-vaccination reactions after COVID-19 vaccines in poland. Report for the period 27.12.2020–15.12.2021 (2021). https://www.pzh.gov.pl/wp-content/uploads/2021/12/Raport-NOP-do-15.12.2021.pdf
Zhou, M. et al. Dilution or enrichment: the effects of flood on pollutants in urban rivers. Environ. Sci. Europe. 34, 61. https://doi.org/10.1186/s12302-022-00639-7 (2022).
IQVIA. Structure and dynamics of the pharmaceutical market, physician and patient behaviour, and drug distributions in 2020 – key facts. (2021).
US Drug Enforcement Administration. DEA takes additional steps to allow increased production of controlled substances used in COVID-19 care (2020). https://www.dea.gov/press-releases/2020/04/07/dea-takes-additional-steps-allow-increased-production-controlled
Omotola, E. O. & Olatunji, O. S. Quantification of selected pharmaceutical compounds in water using liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS). Heliyon 6, e05787. https://doi.org/10.1016/j.heliyon.2020.e05787 (2020).
Pierce, M. et al. Mental health before and during the COVID-19 pandemic: a longitudinal probability sample survey of the UK population. Lancet Psychiatry. 7, 883–892. https://doi.org/10.1016/S2215-0366(20)30308-4 (2020).
Rogers, A. H., Shepherd, J. M., Garey, L. & Zvolensky, M. J. Psychological factors associated with substance use initiation during the COVID-19 pandemic. Psychiatry Res. 293, 113407. https://doi.org/10.1016/j.psychres.2020.113407 (2020).
Ettman, C. K. et al. Prevalence of depression symptoms in US adults before and during the COVID-19 pandemic. JAMA Netw. Open. 3, e2019686. https://doi.org/10.1001/jamanetworkopen.2020.19686 (2020).
Yang, R. et al. Increased antipsychotic drug concentration in hospitalized patients with mental disorders following COVID-19 infection: a call for attention. Front. Psychiatry. 15, 1421370. https://doi.org/10.3389/fpsyt.2024.1421370 (2024).
Nobili, A. et al. Post-COVID condition: dispensation of drugs and diagnostic tests as proxies of healthcare impact. Intern. Emerg. Med. 18, 801–809. https://doi.org/10.1007/s11739-023-03228-5 (2023).
Mooses, K. et al. The use of prescription drugs and health care services during the 6-month post-COVID-19 period. Sci. Rep. 13, 11638. https://doi.org/10.1038/s41598-023-38691-9 (2023).
Cho, Y., Yeo, I. H., Lee, D. E. & Kim, J. K. Coronavirus disease pandemic impact on emergency department visits for cardiovascular disease in korea: A review. Medicine 102, e35992. https://doi.org/10.1097/MD.0000000000035992 (2023).
