Study: Cannabis Provides Sustained Relief for Patients With Treatment-Resistant Depression
Study: Cannabis Provides Sustained Relief for Patients With Treatment-Resistant Depression
Study: Cannabis Provides Sustained Relief for Patients With Treatment-Resistant Depression
Study: Cannabis Provides Sustained Relief for Patients With Treatment-Resistant Depression
22 Comments
It’s got a lot of good quality uses. It’s a shame that many people don’t realize it can be abused like any other drug.
I hope that a proper dosage for things like THC can be determined in the future for medication use. Not to restrict access to the substance but to protect at risk people from substance abuse due to many of the popular misconceptions about cannabis and addiction.
It’s been helping with mine so far but I rather seek better options soon
“Further randomized controlled trials, stratified by comorbidity profiles and product composition, are required to confirm efficacy, optimize treatment regimens, and clarify long-term safety.”
This is correlational study with an egregiously inaccurate headline. We can not infer causation from this.
Furthermore, this article is hosted on a website about advocacy for marijuana legalization. There could not be a stronger risk of bias.
This is great news. More research like this may actually lead to proper funding. The more people are aware of the medical benefits, the more they can pursue harm reduction behaviors by choosing to use THC instead of self-medicating with way, way more harmful things like alcohol. And for those who may not react well to other psychiatric drugs.
It was helping me quite a bit, but no amount of weed, SSRI’s, nor therapy can make the environment you live in better if it’s the cause of your depression and anxiety.
It works but it has downsides. It can blunt cognitive ability and presence of mind. I’d rather have something that lets my mind stay sharp, but I can’t find anything that works. Weed feels great though. It actually makes me want to exercise and be active
It has definitely helped me. I also have PTSD and bipolar 2. It has definitely helped.
These are observational data from a registry of medicinal cannabis recipients at a private clinic in the UK.
There’s no control group, and the group is inherently selected both by enrollment (with most being current cannabis users), and by outcome (patients had to have a long enough follow up time to be in the study; the outcomes are based on questionnaire responses, and people doing well are much more likely to fill these in, making imputation unreliable).
These data can’t say anything robust about the effect of cannabis on treatment resistant depression.
“Across all prescription types, the THC doses increased steadily over time, reaching a median dose of 220.00 mg/day [116.00–258.50 mg/day] at 18 months before remaining stable thereafter.”
That seems like so much THC! Products by me are dosed at 2.5/4/10/15mg. Taking 220mg of THC per day seems so high, pun not intended but definitely applies.
I’ve struggled with depression for decades and recently quit smoking weed because I felt like it was making things worse instead of better. I was a daily smoker for 10 years. YMMV.
I find it sad how demonized marijuana still is. It has very useful medicinal qualities but it’s still talked about as if we’re in the middle of reefer madness
https://www.sciencedirect.com/science/article/pii/S0165032725025728
Major gripes:
No random assignment
Not a double-blind, or even a single-blind experiment
No placebo control groups
This article mentions nothing about using marijuana alongside taking psychiatric medications. DO NOT take them together. I’m sure there are people here with survivor bias but there are serious side effects, both mental and physical. It’s super important to consult a psychiatrist before using marijuana if you’re mentally ill and on meds. Take it from someone who had a psychotic break from it because I wasn’t properly educated on the risks
A less press release version of the information is at https://www.sciencedirect.com/science/article/pii/S0165032725025728
The TL:DR is that some cannabis companies funded research that suggests more research would be a good idea.
Interesting! Cannabis makes me feel good in the moment but afterwards I slip into total despair and panic. I am jealous of those it helps.
For anyone curious about how a registry study works, this is basically real world patients tracked over time not a placebo controlled trial, so we need trials but the real life signal is interesting
The fact that this study found sustained improvement, not just short term change, is what sets it apart. That’s the type of data clinicians need before they’ll start thinking beyond SSRIs.
It has definitely worked for me.
Yeah, when you aren’t surrounded by people projecting their trauma onto you and treating you different after they find out you were high every time before they ever knew.
Otherwise, your mileage will vary.
Now try the study with psilocybin.
sure, until it gives you a whole different form of anxiety and depression
THC like any drug can have both negative and positiveeffects. It can also increase suicidal ideations in those with TRD as well.
You’re better off getting TMS, ketamine/esketamine, or psilocybin treatments than cannabis due to their efficacy.