> The future of heart attack prevention could be as easy as a single injection.
> The treatment, called VERVE-102, could transform the future of heart attack prevention by dramatically reducing a person’s levels of LDL cholesterol – the so-called ‘bad’ cholesterol – with just one injection. While statins can lower a person’s cholesterol levels by similar levels, these generally need to be taken daily.
> “This is the future,” Prof Riyaz Patel – an academic cardiologist at University College London and a doctor at Barts Health NHS Trust, which has taken part in the trial.
> “This is reality; it’s not science fiction. We’re actually doing it. I’ve had patients of mine in the trial receive this one-and-done treatment, and it’s going to change the face of cholesterol management going forward.”
> Instead of managing cholesterol over time like statins, VERVE-102 aims to provide a one-time fix by ‘switching off’ a specific gene, known as PCSK9, in the liver. This gene plays a key role in regulating how much LDL cholesterol the liver can detect and remove from the bloodstream.
> Essentially, **less PCSK9 leads to less LDL in the bloodstream.**
> “We’re seeing some spectacular results,” said Patel. “**This drug turns off a tiny fraction of DNA, and your LDL cholesterol is lower by 50 per cent for the rest of your life.** That’s it. One and done.
Ok_Elk_638 on
Cholesterol is not LDL, cholesterol does not cause heart attacks, LDL does not cause heart attacks, elevated levels of LDL in the blood stream does not cause heart attacks. This drug will do nothing of value.
Steveee-O on
I’m pretty sure anyone who is up to date on the science understands cholesterol is not the culprit in heart disease and there are several key factors in place. I really hope this drug never comes around or else we’re doomed to old demented people. WE NEED CHOLESTEROL. STOP THE STATINS. Eat unprocessed foods and exercise
gza_liquidswords on
This is gene therapy. We will see but I think it unlikely to be translated for primary prevention for general public
Bingomancometh on
There are two different kinds of ldls, correct? Does this affect both?
kesor on
You can also cut cholesterol by 100% if you pull out your liver, and then all your cells will quickly die due to lack of energy. Stop with these stupid ideas, cholesterol is good for you, your body is making 90% of your cholesterol on its own, because it is mandatory, and people with high cholesterol live longer (according to actual studies).
An overview of a dozen studies and a better explanation of how cholesterol is taught at medicine schools vs. how it actually works. [https://youtu.be/rdgS3PuSuyg](https://youtu.be/rdgS3PuSuyg)
Dr. Mason also shows a medical device that is measuring the LDL particles and compares the oxidized ones vs. the normal ones. Clearly showing that lower LDL has nothing to do with coronary disease risk factors.
There are multiple other doctors who explain these things, and have been for years. Dr. Ali Nadir, Dr. Pradip Jamnadas, Dr. Anthony Chaffee, and many others.
rovyovan on
As someone who’s had a heart attack and been told I have a genetic disposition for this problem I feel hopeful yet skeptical
iPinch89 on
LDL isn’t the lipid you think it is. It’s actually alien DNA that’s been injected into humans in the time of the pyramids, that’s why pyramids and the chemical structure of LDL look identical.
Sorry, I’m doing the same thing everyone else is doing in this thread, making fully unsubstantiated claims without citation.
To those of you posting about how big pharma faked studies to make LDL look like the bad guy and it’s actually not a problem….do you have sources? I’m a random lay person, so if youre going to say the opposite of my doctor’s, I’m going to need some proof.
To be clear, my first paragraph is satire.
CodyLeet on
The pharmaceutical industry will never allow this to come to market because they make too much profit off statins.
Black_RL on
>“We’re seeing some spectacular results,” said Patel. “This drug turns off a tiny fraction of DNA, and your LDL cholesterol is lower by 50 per cent for the rest of your life. That’s it. One and done.
Wait…… this is like a miracle….. we’re living/seeing such amazing things, and AI is just getting started!
Why can’t we be friends…..
When will this be available to all of us?
TotallyJawsome2 on
Excellent. Now I can consume prilosec before gobbling down 30 cheese burgers for the heartburn, stab some ozempic in my thigh so i stay nice and skinny, wash down the burgers with a triple double chocolate shake, take my insulin injection so my feet don’t fall off, then just wipe out the cholesterol with this new concoction. Now I can get rid of my anxiety medication since I don’t live in crippling fear of having a heart attack before I’m 40
metalgod on
If you think the covid vaccine science is a scam you shouldn’t be allowed to take this.
Trumpassassin777 on
I do get the psk9 injection every two weeks. My ldl went from 95 to 14 in 6 weeks.
_Faucheuse_ on
Gonna have the healthiest obese people alive. Well, heart healthy at least. “Pass me that triple baconator with chili cheese fries. Diet coke?! I just got the shot, *I want the good stuff.*”
Schmancer on
Does this treatment work better than eating lots of vegetables and participating in regular, vigorous exercise?
JadieRose on
So do people who pursue this treatment get accused of “cheating” the same way people on GLP-1 drugs do?
GWtech on
But what about the fact that cholesterol has many good benefits and there have been a lot of problems associated with lowering cholesterol. Would this also create the same problems?
whatmepolo on
Just watched The Fugitive today. Should have called it Provasic
snuggl3ninja on
Why does over clocking you live sound like it would be a bad idea. I suppose if the alternative is heart failure it’s different.
19 Comments
> The future of heart attack prevention could be as easy as a single injection.
> The treatment, called VERVE-102, could transform the future of heart attack prevention by dramatically reducing a person’s levels of LDL cholesterol – the so-called ‘bad’ cholesterol – with just one injection. While statins can lower a person’s cholesterol levels by similar levels, these generally need to be taken daily.
> “This is the future,” Prof Riyaz Patel – an academic cardiologist at University College London and a doctor at Barts Health NHS Trust, which has taken part in the trial.
> “This is reality; it’s not science fiction. We’re actually doing it. I’ve had patients of mine in the trial receive this one-and-done treatment, and it’s going to change the face of cholesterol management going forward.”
> Instead of managing cholesterol over time like statins, VERVE-102 aims to provide a one-time fix by ‘switching off’ a specific gene, known as PCSK9, in the liver. This gene plays a key role in regulating how much LDL cholesterol the liver can detect and remove from the bloodstream.
> Essentially, **less PCSK9 leads to less LDL in the bloodstream.**
> “We’re seeing some spectacular results,” said Patel. “**This drug turns off a tiny fraction of DNA, and your LDL cholesterol is lower by 50 per cent for the rest of your life.** That’s it. One and done.
Cholesterol is not LDL, cholesterol does not cause heart attacks, LDL does not cause heart attacks, elevated levels of LDL in the blood stream does not cause heart attacks. This drug will do nothing of value.
I’m pretty sure anyone who is up to date on the science understands cholesterol is not the culprit in heart disease and there are several key factors in place. I really hope this drug never comes around or else we’re doomed to old demented people. WE NEED CHOLESTEROL. STOP THE STATINS. Eat unprocessed foods and exercise
This is gene therapy. We will see but I think it unlikely to be translated for primary prevention for general public
There are two different kinds of ldls, correct? Does this affect both?
You can also cut cholesterol by 100% if you pull out your liver, and then all your cells will quickly die due to lack of energy. Stop with these stupid ideas, cholesterol is good for you, your body is making 90% of your cholesterol on its own, because it is mandatory, and people with high cholesterol live longer (according to actual studies).
An overview of a dozen studies and a better explanation of how cholesterol is taught at medicine schools vs. how it actually works. [https://youtu.be/rdgS3PuSuyg](https://youtu.be/rdgS3PuSuyg)
Dr. Mason also shows a medical device that is measuring the LDL particles and compares the oxidized ones vs. the normal ones. Clearly showing that lower LDL has nothing to do with coronary disease risk factors.
There are multiple other doctors who explain these things, and have been for years. Dr. Ali Nadir, Dr. Pradip Jamnadas, Dr. Anthony Chaffee, and many others.
As someone who’s had a heart attack and been told I have a genetic disposition for this problem I feel hopeful yet skeptical
LDL isn’t the lipid you think it is. It’s actually alien DNA that’s been injected into humans in the time of the pyramids, that’s why pyramids and the chemical structure of LDL look identical.
Sorry, I’m doing the same thing everyone else is doing in this thread, making fully unsubstantiated claims without citation.
To those of you posting about how big pharma faked studies to make LDL look like the bad guy and it’s actually not a problem….do you have sources? I’m a random lay person, so if youre going to say the opposite of my doctor’s, I’m going to need some proof.
To be clear, my first paragraph is satire.
The pharmaceutical industry will never allow this to come to market because they make too much profit off statins.
>“We’re seeing some spectacular results,” said Patel. “This drug turns off a tiny fraction of DNA, and your LDL cholesterol is lower by 50 per cent for the rest of your life. That’s it. One and done.
Wait…… this is like a miracle….. we’re living/seeing such amazing things, and AI is just getting started!
Why can’t we be friends…..
When will this be available to all of us?
Excellent. Now I can consume prilosec before gobbling down 30 cheese burgers for the heartburn, stab some ozempic in my thigh so i stay nice and skinny, wash down the burgers with a triple double chocolate shake, take my insulin injection so my feet don’t fall off, then just wipe out the cholesterol with this new concoction. Now I can get rid of my anxiety medication since I don’t live in crippling fear of having a heart attack before I’m 40
If you think the covid vaccine science is a scam you shouldn’t be allowed to take this.
I do get the psk9 injection every two weeks. My ldl went from 95 to 14 in 6 weeks.
Gonna have the healthiest obese people alive. Well, heart healthy at least. “Pass me that triple baconator with chili cheese fries. Diet coke?! I just got the shot, *I want the good stuff.*”
Does this treatment work better than eating lots of vegetables and participating in regular, vigorous exercise?
So do people who pursue this treatment get accused of “cheating” the same way people on GLP-1 drugs do?
But what about the fact that cholesterol has many good benefits and there have been a lot of problems associated with lowering cholesterol. Would this also create the same problems?
Just watched The Fugitive today. Should have called it Provasic
Why does over clocking you live sound like it would be a bad idea. I suppose if the alternative is heart failure it’s different.