Ketamine repairs reward circuitry to reverse stress-induced anhedonia
Ketamine repairs reward circuitry to reverse stress-induced anhedonia
Ketamine repairs reward circuitry to reverse stress-induced anhedonia
Ketamine repairs reward circuitry to reverse stress-induced anhedonia
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Ketamine rapidly treats depression’s anhedonia (loss of pleasure) symptom by repairing specific brain connections in the nucleus accumbens. In stressed mice, a single ketamine dose restored reward-seeking behavior within hours by strengthening synapses on dopamine D1 neurons from prefrontal cortex and hippocampus pathways.
Identifying specific synapses that support antidepressant effects may eventually allow researchers to design drugs that improve motivation without the dissociative side effects associated with ketamine.
Aw don’t tell me this.
I absolutely cannot afford ketamine therapy, unfortunately. I can say I’ve experienced the therapeutic effects before and they were great, but I absolutely *loathed* the sensations felt from recreational dosages.
Maybe this is why ol’ Leon was high on it constantly.
Most redditors now “Yea but what about Elon and Matthew Perry”.
*[While earlier definitions emphasized the inability to experience pleasure, anhedonia is currently used by researchers to refer to reduced motivation, reduced anticipatory pleasure (wanting), reduced consummatory pleasure (liking), and deficits in reinforcement learning]*
now your broken if you don’t thumbs up
Interesting. I havent noticed this personally. Reward seeking is something I feel like I don’t have and wish Ketamine would restore.
Seeing all the kids burnt out on K at Raves in the late 90s I’d beg to differ any positive effects
can someone do a study on how all the tech bros doing ketamine are still greedy control freaks bent on technofascism?
This is fascinating stuff. The fact that they can pinpoint exactly which brain circuits ketamine fixes could be huge for developing better depression treatments without the trippy side effects