Guess we’re officially entering the DLC era for human knees science just dropped the cartilage expansion pack.
PROMPTIFA on
How soon can I order?
pearlyeti on
This is how we get I Am Legend. The bad movie version.
Reasonabledwarf on
The scourge of arthritis in mice is finally at an end!
Masterofunlocking1 on
Shoot that shit all in my knees!!!
Content-Fudge489 on
Where can I get it? Like ASAP?
jackatman on
Snowboarder and runner in his forties. Yesterday please.
Vynaca on
Can we do this between vertebrae yet?
Acrobatic-Towel-6488 on
Do I have to go to Mexico? Because I’ll go to Mexico. I’ve heard they do stem cells for cheap, right in the knee. I needed that yesterday
Astrocoder on
Wint be ready for 10 or more years if ever
sweetnsourgrapes on
This sounds fairly significant and currently undergoing clinical trials.
> The therapy targets a protein called 15-PGDH, which becomes more abundant as the body ages and is classified as a gerozyme. Gerozymes, first described by the same research team in 2023, play a central role in aging by contributing to the gradual decline of tissue function. In mice, rising levels of 15-PGDH are a key factor in the loss of muscle strength that occurs with age. When scientists block this protein using a small molecule, older mice show gains in muscle mass and endurance. In contrast, forcing young mice to produce 15-PGDH causes their muscles to weaken and shrink. The protein has also been linked to the regeneration of bone, nerve, and blood cells.
> …
> Further experiments confirmed that the chondrocytes in the joint were generating hyaline, or articular, cartilage, rather than less-functional fibrocartilage.
> …
> Finally, the researchers studied human cartilage tissue removed from patients with osteoarthritis undergoing total knee replacements. Tissue treated with the 15-PGDH inhibitor for one week exhibited lower levels of 15-PGDH-expressing chondrocytes and lowered cartilage degradation and fibrocartilage genes than control tissue and began to regenerate articular cartilage.
> Blau added, “Phase 1 clinical trials of a 15-PGDH inhibitor for muscle weakness have shown that it is safe and active in healthy volunteers. Our hope is that a similar trial will be launched soon to test its effect in cartilage regeneration. We are very excited about this potential breakthrough. Imagine regrowing existing cartilage and avoiding joint replacement.”
TJPII-2 on
Would it work for degeneration of cartilage between the discs of the spine?
Wizzle-Stick on
so… where do i sign up for human trials? i got an injection tuesday to add some juice back to one of my knees. it would be awesome to not need those anymore.
STARoSCREAM on
Does it work in shoulders that are bone on bone?
toofshucker on
Let Joel Embiid know!!!!
uniklyqualifd on
Trump fired the researchers.
raerae1991 on
Does this work on hip joints too?
deftdabler on
Will likely cost an arm and a leg though
Apprehensive_Neat418 on
My gf wil so happy again!!
KingIVXX on
Army needs to buy a stockpile
nwerdnerd on
Isnt this how resident evil starts ?
murdog74 on
Oh my God. Please take my money and give it to me now!
Graybeard_Shaving on
Calling bullshit on this one. Not just the normal level of bullshit either… the uber doober level of bullshit.
NOGOODGASHOLE on
I’m 55, but still have 2 years of college athletic eligibility. My NIL money would cover the injections is they’d just front me.
Candle-Jolly on
INJECT IT INTO MY ~~VEINS~~ KNEES
tonyislost on
We’re wasting money on this when we could be giving it to Elon who needs it for his robots and Trump for his ballroom. What are we even doing America!?
FrankSamples on
Why is the NBA and NFL not investing massively into this?
kaishinoske1 on
It’s either this or a new knee in a decade. We shall see which comes first.
imhereforthemeta on
100 percent I will be on this shit. I have cartilage degeneration and missing cartilage from a rupture on both knees. This would change my life
inlinestyle on
Tick tock, science. Just turned 50 and need you to pick the pace please.
Lucklessdrip on
Holy shit I NEED THIS SHIT, im in my early twenty’s but I cant even run anymore because of arthritis.
MidEastBeast on
People will willingly put this in their bodies, but won’t trust vaccines that have been thoroughly studied and proven safe for decades. smh people are dumb.
robogobo on
Looking forward to this being bought up and never heard from again
57_Eucalyptusbreath on
And where would one find such a shot….asking for a friend.
Seriously. My friend has next to no cartilage in her knees and it’s 24/7 pain for her.
I now need to have a chat with people at Stanford.
35 Comments
Guess we’re officially entering the DLC era for human knees science just dropped the cartilage expansion pack.
How soon can I order?
This is how we get I Am Legend. The bad movie version.
The scourge of arthritis in mice is finally at an end!
Shoot that shit all in my knees!!!
Where can I get it? Like ASAP?
Snowboarder and runner in his forties. Yesterday please.
Can we do this between vertebrae yet?
Do I have to go to Mexico? Because I’ll go to Mexico. I’ve heard they do stem cells for cheap, right in the knee. I needed that yesterday
Wint be ready for 10 or more years if ever
This sounds fairly significant and currently undergoing clinical trials.
> The therapy targets a protein called 15-PGDH, which becomes more abundant as the body ages and is classified as a gerozyme. Gerozymes, first described by the same research team in 2023, play a central role in aging by contributing to the gradual decline of tissue function. In mice, rising levels of 15-PGDH are a key factor in the loss of muscle strength that occurs with age. When scientists block this protein using a small molecule, older mice show gains in muscle mass and endurance. In contrast, forcing young mice to produce 15-PGDH causes their muscles to weaken and shrink. The protein has also been linked to the regeneration of bone, nerve, and blood cells.
> …
> Further experiments confirmed that the chondrocytes in the joint were generating hyaline, or articular, cartilage, rather than less-functional fibrocartilage.
> …
> Finally, the researchers studied human cartilage tissue removed from patients with osteoarthritis undergoing total knee replacements. Tissue treated with the 15-PGDH inhibitor for one week exhibited lower levels of 15-PGDH-expressing chondrocytes and lowered cartilage degradation and fibrocartilage genes than control tissue and began to regenerate articular cartilage.
> Blau added, “Phase 1 clinical trials of a 15-PGDH inhibitor for muscle weakness have shown that it is safe and active in healthy volunteers. Our hope is that a similar trial will be launched soon to test its effect in cartilage regeneration. We are very excited about this potential breakthrough. Imagine regrowing existing cartilage and avoiding joint replacement.”
Would it work for degeneration of cartilage between the discs of the spine?
so… where do i sign up for human trials? i got an injection tuesday to add some juice back to one of my knees. it would be awesome to not need those anymore.
Does it work in shoulders that are bone on bone?
Let Joel Embiid know!!!!
Trump fired the researchers.
Does this work on hip joints too?
Will likely cost an arm and a leg though
My gf wil so happy again!!
Army needs to buy a stockpile
Isnt this how resident evil starts ?
Oh my God. Please take my money and give it to me now!
Calling bullshit on this one. Not just the normal level of bullshit either… the uber doober level of bullshit.
I’m 55, but still have 2 years of college athletic eligibility. My NIL money would cover the injections is they’d just front me.
INJECT IT INTO MY ~~VEINS~~ KNEES
We’re wasting money on this when we could be giving it to Elon who needs it for his robots and Trump for his ballroom. What are we even doing America!?
Why is the NBA and NFL not investing massively into this?
It’s either this or a new knee in a decade. We shall see which comes first.
100 percent I will be on this shit. I have cartilage degeneration and missing cartilage from a rupture on both knees. This would change my life
Tick tock, science. Just turned 50 and need you to pick the pace please.
Holy shit I NEED THIS SHIT, im in my early twenty’s but I cant even run anymore because of arthritis.
People will willingly put this in their bodies, but won’t trust vaccines that have been thoroughly studied and proven safe for decades. smh people are dumb.
Looking forward to this being bought up and never heard from again
And where would one find such a shot….asking for a friend.
Seriously. My friend has next to no cartilage in her knees and it’s 24/7 pain for her.
I now need to have a chat with people at Stanford.
Joel Embiid step right up