>The treatment converted the liver into an immune cell “nursery” that pumped out greater numbers of healthy T cells.
>our immunity loses power as we age. Immune cells dwindle, and those that remain struggle to perform their usual roles. As a result, immune defenses weaken, increasing the chances of infection and cancer. This also makes vaccines less effective in older adults.
>Now, a new treatment using mRNA technology similar to that in Covid vaccines rejuvenated the immune systems of old mice with twice-weekly shots.
>Resetting immunity isn’t just about defense. The immune system is intricately tied to the health of other organs. Chronic inflammation steadily rises as we age, wreaking havoc on memory, cognition, and metabolism. It also stiffens tissues in multiple organs, increasing the chances of heart attacks and kidney failure.
>Baby T cells then journey to the thymus, a small organ sitting at the top of the heart, where they mature and diversify. In this nursery, the cells learn friend from foe, ensuring they’ll only attack legitimate threats while leaving healthy cells alone.
>The aging process gradually degrades the nursery. The thymus shrinks, and much of its working tissue is replaced by fat, leading to a drop in newly minted T cells.
>Rather than reviving the struggling organ, the team built a new T cell nursery in another part of the body. They decided on the liver as a temporary nursery for several reasons. The organ faithfully synthesizes proteins even into old age, and it’s a relatively easy target for mRNA treatments.
CiraKazanari on
Man we are breeding some super-mice and they’re gonna become the dominant species
Redwall is about to become fact
arcalumis on
Ok, and would that shot do ANYTHING in humans? I’m so effing tired of shit that work in field mice but of course wouldn’t work in a human.
So why are they using mice to begin with?
agentobtuse on
As someone with MS my bcells failed thalamus university and tell my t cells to kill the host. I would argue my immune system is in some over drive state bored and looking for fight like teenage angst. Give me the mRNA shot that corrects my gift please …I hate MS so much….
ChipSome6055 on
Such a shame that mRNA vaccines will be banned by the trump administration
ZanzibarGuy on
We gotta research stuff like this because it allows the powers that be to continue to raise the age of retirement.
6 Comments
>The treatment converted the liver into an immune cell “nursery” that pumped out greater numbers of healthy T cells.
>our immunity loses power as we age. Immune cells dwindle, and those that remain struggle to perform their usual roles. As a result, immune defenses weaken, increasing the chances of infection and cancer. This also makes vaccines less effective in older adults.
>Now, a new treatment using mRNA technology similar to that in Covid vaccines rejuvenated the immune systems of old mice with twice-weekly shots.
>Resetting immunity isn’t just about defense. The immune system is intricately tied to the health of other organs. Chronic inflammation steadily rises as we age, wreaking havoc on memory, cognition, and metabolism. It also stiffens tissues in multiple organs, increasing the chances of heart attacks and kidney failure.
>Baby T cells then journey to the thymus, a small organ sitting at the top of the heart, where they mature and diversify. In this nursery, the cells learn friend from foe, ensuring they’ll only attack legitimate threats while leaving healthy cells alone.
>The aging process gradually degrades the nursery. The thymus shrinks, and much of its working tissue is replaced by fat, leading to a drop in newly minted T cells.
>Rather than reviving the struggling organ, the team built a new T cell nursery in another part of the body. They decided on the liver as a temporary nursery for several reasons. The organ faithfully synthesizes proteins even into old age, and it’s a relatively easy target for mRNA treatments.
Man we are breeding some super-mice and they’re gonna become the dominant species
Redwall is about to become fact
Ok, and would that shot do ANYTHING in humans? I’m so effing tired of shit that work in field mice but of course wouldn’t work in a human.
So why are they using mice to begin with?
As someone with MS my bcells failed thalamus university and tell my t cells to kill the host. I would argue my immune system is in some over drive state bored and looking for fight like teenage angst. Give me the mRNA shot that corrects my gift please …I hate MS so much….
Such a shame that mRNA vaccines will be banned by the trump administration
We gotta research stuff like this because it allows the powers that be to continue to raise the age of retirement.