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    The immune system’s reaction to the common Epstein-Barr Virus (EBV) can damage the brain and contribute to multiple sclerosis (MS). A recent study provides new insight into the long-suspected link between EBV and MS - Long-term memory T-cells pick on the wrong protein (ANO2) instead of EBV-antigen.
    Science

    The immune system’s reaction to the common Epstein-Barr Virus (EBV) can damage the brain and contribute to multiple sclerosis (MS). A recent study provides new insight into the long-suspected link between EBV and MS – Long-term memory T-cells pick on the wrong protein (ANO2) instead of EBV-antigen.


    The immune system’s reaction to the common Epstein-Barr Virus (EBV) can damage the brain and contribute to multiple sclerosis (MS). A recent study provides new insight into the long-suspected link between EBV and MS – Long-term memory T-cells pick on the wrong protein (ANO2) instead of EBV-antigen.

    https://www.clinicallab.com/new-mechanism-links-epstein-barr-virus-to-multiple-sclerosis-28526

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    8 Comments

    2. tsoneyson on

      The list of EBV-associated diseases is long. Is there any possibility of systematic eradication?

    3. triffid_boy on

      So I guess there is a big advantage (as well as potential risk) to antigen selection for vaccines then.

    5. UncleBuckReddit on

      If it is estimated 90-95% of US adults have had an EBV infection- is there any additional context on who, in that group, is at the most risk?

    6. AbusedGoat on

      So this is another case of EBV using molecular mimicry to have the immune system attack itself. I believe EBV is also strongly associated as a cause of Hashimoto’s disease.

      There’s something I’ve wondered about regarding EBV and molecular mimicry: if the body is basically identifying something else as too similar and attacking itself is it possible to give people a vaccine in such a way that people most likely to develop improper autoimmune responses can have their immune system pre-trained to identify those viruses in a way that doesn’t get misinterpreted?

      This would be /before/ somebody is ever infected with it. But if somebody’s family has a history of an autoimmune disease triggered by EBV I would think it’s maybe possible to present it to the immune system in a different way.

    8. Rickydada on

      I wonder how this ties to MECFS given their are a lot of ppl that got MECFS after EBV infection