Frontiers | DXM, CYP2D6-inhibiting antidepressants, piracetam, and glutamine: proposing a ketamine-class antidepressant regimen with existing drugs
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1751605/full
Frontiers | DXM, CYP2D6-inhibiting antidepressants, piracetam, and glutamine: proposing a ketamine-class antidepressant regimen with existing drugs
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2026.1751605/full
2 Comments
Reading this science is so wild to me compared to how I’ve been treated by people in authority for using these exact substances to treat my fibromyalgia. Low dose dxm, I utilized that in 2011 and it was astounding to like wake up out of a fog and be effective. I’ve settled on noopept for the racetam. I cycle on and off. Ketamine is unwieldy imo. It obviously helps but who can afford the clinics, and it can be super intense. But it’s obviously effective for down regulating wind up pain and nervous energy. I know this is about depressive disorders but I view my condition as hyper-excitatory nervous system with sleep disruption and mitochondrial dysfunction. Leading to dysregulation of energy. But now twenty five years later I have almost full function again.
My other publications related to the Regimen:
Cheung N. (2026). The Cheung Glutamatergic Regimen as a candidate for primary and secondary prevention of Alzheimer’s disease onset. Journal of Alzheimer’s Disease Reports, 10, 25424823261433953. [https://doi.org/10.1177/25424823261433953](https://doi.org/10.1177/25424823261433953)
Cheung N. (2026). A Developmental Taxonomy of Autism and the Precision Timing of the Cheung Glutamatergic Regimen. Cureus, 18(4), e107120. [https://doi.org/10.7759/cureus.107120](https://doi.org/10.7759/cureus.107120)
Cheung, N. (2026). Oral glutamatergic modulation with dextromethorphan and piracetam for refractory bipolar disorder with obsessive-compulsive disorder: Three consecutive cases from routine practice. Journal of Clinical Psychiatry, 87(2), Article 25cr16262.
Cheung N. (2026). Case Report: Oral glutamatergic augmentation for trauma-related disorders with fluoxetine-/bupropion-potentiated dextromethorphan ± piracetam: a four-patient case series. Frontiers in Psychiatry, 17, 1752101. [https://doi.org/10.3389/fpsyt.2026.1752101](https://doi.org/10.3389/fpsyt.2026.1752101)
Cheung N. (2026, February 21). Glutamatergic Enhancement Using As-Needed Dextromethorphan and Piracetam in a Stimulant-Partially Responsive Adult With ADHD: A Single-Case Report. Cureus, 18(2), e104031. [https://doi.org/10.7759/cureus.104031](https://doi.org/10.7759/cureus.104031)
Cheung N. (2026, February 24). Transient Mood Elevation Without a Manic Switch: Goldenseal-Augmented Oral Glutamatergic Regimen in Bipolar Depression With Comorbid Obsessive-Compulsive Disorder (OCD). Cureus, 18(2), e104209. [https://doi.org/10.7759/cureus.104209](https://doi.org/10.7759/cureus.104209)
Cheung N. (2026, March 3). Marked Improvement in Treatment-Intolerant Obsessive-Compulsive Disorder in an Adolescent Using a Glutamatergic Regimen With Dextromethorphan, Piracetam, and Goldenseal Root. Cureus, 18(3), e104617. [https://doi.org/10.7759/cureus.104617](https://doi.org/10.7759/cureus.104617)
Cheung N. (2026, March 17). Inhibitor-Free Variant of the Cheung Regimen: Successful Adjunctive Therapy in Long-Standing Hypochondriasis With Prominent Somatic Features. Cureus, 18(3), e105367. [https://doi.org/10.7759/cureus.105367](https://doi.org/10.7759/cureus.105367)
Cheung N. (2026, May 10). Longitudinal Management of Post-traumatic Brain Injury Bipolar-Spectrum Disorder With Low-Dose Oral Glutamatergic Augmentation: Extended Follow-Up Revealing Induction, Overshoot, Stabilization, and Transition to PRN Maintenance. Cureus, 18(5), e108595. [https://doi.org/10.7759/cureus.108595](https://doi.org/10.7759/cureus.108595)
Cheung N. (2026, May 12). Longitudinal Outcomes of Oral Glutamatergic Augmentation in Trauma-Related Dissociation: A Six-Month Case Study. Cureus, 18(5), e108751. [https://doi.org/10.7759/cureus.108751](https://doi.org/10.7759/cureus.108751)