
A breakthrough in electron microscopy delivers sharper images of our body’s tiniest proteins: « UC Berkeley physicists have introduced phase contrast to the electron microscope, allowing scientists to see much smaller molecules and smaller structures inside cells. »
https://news.berkeley.edu/2026/06/11/a-breakthrough-in-electron-microscopy-delivers-sharper-images-of-our-bodys-tiniest-proteins/

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« With cryo-ET, we’re looking at small, very complicated cellular material that’s incredibly crowded inside the cell. It’s like a forest of trees, and you’re trying to find one leaf on one tree in there. Cryo-ET needs a dramatic step forward in contrast, so we can start to see what’s going on inside the cell. That’s what the laser phase plate promises to give us. »
Reference: Petar N. Petrov *et al.*, Laser phase plate improves structure determination of small proteins by cryo-EM. *Science* **0**, eaeh0665. DOI: [10.1126/science.aeh0665.](https://doi.org/10.1126/science.aeh0665) [https://www.science.org/doi/10.1126/science.aeh0665](https://www.science.org/doi/10.1126/science.aeh0665)