The groundbreaking discovery of a molecular defect underlying systemic lupus erythematosus (lupus) marks a pivotal moment in the treatment of this complex autoimmune disease. By unraveling the intricate relationship between the aryl hydrocarbon receptor (AHR) pathway and the pathological immune response, researchers have opened a promising avenue for developing targeted therapies.
This research prompts a critical discussion on the future landscape of lupus treatment. What are the potential challenges and opportunities in translating this discovery into effective clinical interventions? How can we optimize the delivery and efficacy of AHR pathway modulators? Furthermore, this study raises questions about the broader implications of AHR modulation on immune function and its potential applications in other autoimmune diseases.
mankee81 on
Now the phatmaceutical companies will spend the next few years finding out how to tame the molecule just enough to keep you needing continual doses which they will then sell for 10-30k a year and will inflict horrible side effects on your internal organs.
“If you can’t afford the prescription, AstraZeneca may be able to help!”
avatarname on
Lupus you foul devil, you go! You bow to the name of Jesus!
Eis_Gefluester on
That’s great but rather redundant as it is never lupus.
Logical-Air-1337 on
Awesome news.
Let it be known, I am using the last shreds of my willpower to not make a House reference.
skynil on
I don’t have enough medical knowledge to know if this discovery is actually sound or not, but finding the root cause of Autoimmune conditions and possible cures to treat it better instead of throwing steroids at it will be a game changer for mankind. And why just lupus? Similar autoimmune conditions plague us from simple hayfevers to IBS. I hope science works on this one. Far too long we have suffered from immune related conditions.
CheruB36 on
While this discovery is pivotal for understanding of this disease, there is an upcoming therapy option which is already approved and helped curing people from Lupus
This pathway is also important in the process of Covid pathogenisis https://www.science.org/doi/10.1126/sciadv.adf0211
ah-chamon-ah on
This has stunning implications for all kinds of conditions. As someone with chronic fatigue syndrome for the past 4 years it is the first ray of hope in a 4 year battle of gloomy skies. Specialists. MRI scans. CT blah blah fuckedy blah. I have my fingers crossed.
Dr_Wreck on
So the weirdest thing about lupus to me is that in extremely rare cases, PPIs can trigger the disease.
Does this new information make why that is make sense, at all?
DeepWisdomGuy on
This really just confirms that the treatment was always resveratrol. Too bad it is not patentable and will never make it through clinical trials.
MobileOpposite1314 on
This is fantastic news. My daughter has Lupus and has a shit ton of meds since being diagnosed.
nic-warrior on
I misread the title as “Satanists” and was really confused
BlueKalamari on
I really hope this works I lost a very close friend to lupus, I hope no one else has to go through it anymore.
AlphaMetroid on
That’s great news, too bad it’s never lupus though
15 Comments
The groundbreaking discovery of a molecular defect underlying systemic lupus erythematosus (lupus) marks a pivotal moment in the treatment of this complex autoimmune disease. By unraveling the intricate relationship between the aryl hydrocarbon receptor (AHR) pathway and the pathological immune response, researchers have opened a promising avenue for developing targeted therapies.
This research prompts a critical discussion on the future landscape of lupus treatment. What are the potential challenges and opportunities in translating this discovery into effective clinical interventions? How can we optimize the delivery and efficacy of AHR pathway modulators? Furthermore, this study raises questions about the broader implications of AHR modulation on immune function and its potential applications in other autoimmune diseases.
Now the phatmaceutical companies will spend the next few years finding out how to tame the molecule just enough to keep you needing continual doses which they will then sell for 10-30k a year and will inflict horrible side effects on your internal organs.
“If you can’t afford the prescription, AstraZeneca may be able to help!”
Lupus you foul devil, you go! You bow to the name of Jesus!
That’s great but rather redundant as it is never lupus.
Awesome news.
Let it be known, I am using the last shreds of my willpower to not make a House reference.
I don’t have enough medical knowledge to know if this discovery is actually sound or not, but finding the root cause of Autoimmune conditions and possible cures to treat it better instead of throwing steroids at it will be a game changer for mankind. And why just lupus? Similar autoimmune conditions plague us from simple hayfevers to IBS. I hope science works on this one. Far too long we have suffered from immune related conditions.
While this discovery is pivotal for understanding of this disease, there is an upcoming therapy option which is already approved and helped curing people from Lupus
https://www.fau.eu/2024/07/08/news/worlds-first-car-t-cell-therapy-for-a-child-with-lupus/
This pathway is also important in the process of Covid pathogenisis https://www.science.org/doi/10.1126/sciadv.adf0211
This has stunning implications for all kinds of conditions. As someone with chronic fatigue syndrome for the past 4 years it is the first ray of hope in a 4 year battle of gloomy skies. Specialists. MRI scans. CT blah blah fuckedy blah. I have my fingers crossed.
So the weirdest thing about lupus to me is that in extremely rare cases, PPIs can trigger the disease.
Does this new information make why that is make sense, at all?
This really just confirms that the treatment was always resveratrol. Too bad it is not patentable and will never make it through clinical trials.
This is fantastic news. My daughter has Lupus and has a shit ton of meds since being diagnosed.
I misread the title as “Satanists” and was really confused
I really hope this works I lost a very close friend to lupus, I hope no one else has to go through it anymore.
That’s great news, too bad it’s never lupus though