Scientists have engineered Salmonella bacteria to self-destruct inside tumors, releasing signals that spark powerful immune hubs and shrink colon cancer in mice, opening the door to “living medicines” against deadly cancers.

Tumor-targeting Salmonella engineered to boost colon cancer survival

**Scientists have engineered Salmonella bacteria to self-destruct inside tumors, releasing signals that spark powerful immune hubs and shrink colon cancer in mice, opening the door to “living medicines” against deadly cancers.**

Colorectal cancer is one of the deadliest cancers worldwide, and current immunotherapies often don’t work well to treat it. In an effort to reduce its high mortality rate, scientists are continually seeking new and more effective treatments for colon cancer.

In a new study by the National University of Singapore’s Yong Loo Lin School of Medicine (NUS Medicine) and Central South University, China, researchers have explored a promising avenue in colorectal cancer treatment, boosting special immune cell clusters called mature tertiary lymphoid structures (mTLSs), that form near tumors and are linked to better survival.

For those interested, here’s the link to the peer reviewed journal article:

https://www.science.org/doi/10.1126/scitranslmed.ado8395