RFdiffusion used to design enzymes from scratch to catalyze reactions, opening the door to new proteins that could tackle disease and climate change

https://theconversation.com/enzymes-are-the-engines-of-life-machine-learning-tools-could-help-scientists-design-new-ones-to-tackle-disease-and-climate-change-249565

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  1. **Submission statement:** Most previous efforts to create useful catalytic enzymes have involved modifying existing proteins, even when using machine learning models. But a new approach, published in a new paper in the journal [Science](https://doi.org/10.1126/science.adl2528), started from scratch. After designing the enzymes, the researchers mixed them with their intended molecular target to see whether they could catalyze its breakdown, and they worked, and worked better than previously designed enzymes for the same reaction.